Effectiveness of Dexamethasone, Methylprednisolone and Hydrocortisone Administration on LDH, CRP, D-and PaO2/FiO2 Ratio

Abstract: Steroids are the standard recommended therapy for COVID-19, especially in critically ill patients. Previous studies have shown that steroids beneficial inflammatory markers such as C-Reactive Protein (CRP), Lactate Dehydrogenase (LDH) and D-dimer well value of PaO2/FiO2 ratio. This study aims to determine differences effects steroid’s dexamethasone, methylprednisolone hydrocortisone on markers. research is a retrospective cohort study. The samples were all COVID-19 patients with critical degrees from January June 2021. independent variables hydrocortisone. dependent CRP, LDH, ratio PaO2/FiO2. statistical test used was Kolmogorov-Smirnov continued Kruskal-Wallis Mann-Whitney U test. A total 148 subjects sample dexamethasone 60, 55 33. results showed significant difference effect steroid (p=0.04). Administration statistically superior increasing